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Search Results to Lori Gail Sussel

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Sussel, Lori

One or more keywords matched the following items that are connected to Sussel, Lori

Item Type	Name
Academic Article	Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.
Academic Article	Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.
Concept	Insulin-Secreting Cells
Academic Article	Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Academic Article	The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.
Academic Article	FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
Academic Article	Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.
Academic Article	Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.
Academic Article	Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.
Academic Article	Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.
Academic Article	Nkx2.2 repressor complex regulates islet ?-cell specification and prevents ?-to-a-cell reprogramming.
Academic Article	Pancreatic ? cell dedifferentiation as a mechanism of diabetic ? cell failure.
Academic Article	Human ? cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
Academic Article	Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.
Academic Article	The endocrine pancreas: insights into development, differentiation, and diabetes.
Academic Article	?-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article	?-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
Academic Article	Noncoding RNAs in ? cell biology.
Academic Article	Epigenetic modifications and long noncoding RNAs influence pancreas development and function.
Academic Article	Pancreatic islet cell development and regeneration.
Academic Article	?linc1 encodes a long noncoding RNA that regulates islet ?-cell formation and function.
Academic Article	Pancreatic ? cell identity requires continual repression of non-? cell programs.
Academic Article	LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ? cells.
Academic Article	Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development.
Academic Article	Heterogeneity of the Pancreatic Beta Cell.
Grant	Single Cell Resolution Omics Analysis of T1D islets
Grant	The role of Gata 4 in exocrine pancreas development
Grant	Transcriptional regulation of exocrine development
Grant	Regulation of pancreatic islet cell fate
Grant	Defining the roles of Nkx2.2 and NeuroD in regulating islet cell fate
Academic Article	Gotta Have GATA for Human Pancreas Development.
Academic Article	Notch signaling dynamically regulates adult ? cell proliferation and maturity.
Academic Article	FISHing for ? Cells.
Academic Article	? Cell dysfunction during progression of metabolic syndrome to type 2 diabetes.
Academic Article	Murine Perinatal ?-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1.
Academic Article	Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human ? cell specification.
Grant	PTPN2 mutations affect islet beta cell susceptibility in T1D
Academic Article	Groucho co-repressor proteins regulate ? cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.
Academic Article	Single Molecule-Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet ?-Cells.
Academic Article	Islet Regeneration: Endogenous and Exogenous Approaches.
Academic Article	Inherent Beta Cell Dysfunction Contributes to Autoimmune Susceptibility.
Academic Article	Leveraging the strengths of mice, human stem cells, and organoids to model pancreas development and diabetes.
Academic Article	Not the second fiddle: a cell development, identity, and function in health and diabetes.
Academic Article	Major ? cell-specific functions of NKX2.2 are mediated via the NK2-specific domain.
Academic Article	Modulation of insulin secretion by RBFOX2-mediated alternative splicing.

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Insulin Secreting Cells